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General ScienceMadrid 2026Question 2AFree lesson

X-linked inheritance

A healthy father and a carrier mother: the Punnett square and why it comes out this way

12 chapters · 9 min · Synthetic voices · Press ▶ to startReport a mistakeOpen full screen ↗

Problem statement

Imagine a recessive disease linked to the X chromosome, in which women can be carriers. Suppose that a man who does not have the disease has children with a carrier woman.

a) Draw a diagram of the cross (0.5 marks).

b) State the percentage of normal daughters and of carriers, and that of normal sons and of those who have the disease (1 mark).

c) Give an example of a disease of this type (0.2 marks).

d) Explain the difference between phenotype and genotype. Give an example shown in the Punnett square of part a (0.8 marks).

Source: Madrid university entrance exam (PAU, Spain) · 2025-2026 · Ordinary session · General Science · Question 2A. Official exam set by the public universities of the Community of Madrid, to whom it belongs; translated from Spanish and reproduced with its source in order to explain it for teaching purposes.

What this lesson answers

  1. What does «recessive, X-linked» mean?
  2. Which alleles does each parent carry, and why can a man not be a carrier?
  3. a) What can each parent pass on to their children?
  4. a) The Punnett square, box by box
  5. b) Which percentages come out, and out of what total?
  6. Another route: following each chromosome, without the square
  7. c) A real example: haemophilia
  8. d) What is the difference between genotype and phenotype?
  9. The four answers and how to check the square
  10. Common mistakes you must not make
  11. Exam tips
  12. If you want full marks

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